Cranberry Supplement for BV & UTI Prevention and Relief
Choosing Pacran® was an easy decision once we saw the clinical data completed by Naturex which demonstrated the importance of utilizing a patented cranberry blend that naturally decreases UTI recurrence by 58% when compared to regular cranberry powders.*
Fun Fact: Algonquin Indians, a tribe native to Quebec but widespread throughout North America, were among the first to harvest wild cranberries, having used them for food, medicine, and as a symbol of peace.
Because Transparency Matters:
- Source: South Hackensack, New Jersey
- Active Compound: Proanthocyanidins (PACs)
- Found in:Whole Cranberry Fruit
- What it does: Flushes out bad bacteria from Urinary Tract
- Effective Dosage: 500mg
- Manufaturer: Naturex
The Role of Cranberry Compounds
Cranberries have a strong place in American history. Dating back to the Algonquin Indians, a tribe native to Quebec but widespread throughout North America, Cranberries were among the first to harvest wild cranberries, having used them for food, medicine, and as a symbol of peace.
Today, cranberry juice firmly has its place in society as a common remedy we are introduced to by the women in our lives when UTIs first occur.
Cranberries are filled with amazing compounds like antioxidants and phenolic acids that minimize a bacteria's adhesion property, or their ability to stick to the urinary tract and create infections.
However, there is a vast difference between the cranberries we consume today and those of our ancestors. Due to mass consumption, they aren't as rich in antioxidants as the wild cranberries we use to harvest, and the juices we drink just don't have high amounts of the compounds we need to improve our health.
That's why it's vital to consume a cranberry supplement with a proven source to give you the nutrients you need to keep your V Happy.
Benefits of Pacran®
Reduces the reoccurrence of UTI’sIn a Randomized, Double-Blind, Placebo-Controlled Human Intervention Study which involved 176 women aged 18-60 years, all with at least 1 UTI within the last 12 months, 500mg of Pacran® proved to Reduced UTI recurrence rate by 58% compared to placebo while reducing the overall number of UTIs.
Reduces Bacteria AdhesionThe active antioxidants in cranberries, known as Proanthocyanidins, or PACS, have the ability to inhibit bacterial adhesion. What this means is that bacteria cannot stick to the tissue in the urinary tract, create a biofilm (a collective of bacteria) and cause an infection. And since bacteria cannot latch on, it gets flushed out through the urinary tract. Studies have shown that Pacran® helps reduce the reoccurrence of UTIs and other incidences of E. coli infections.
How Pacran® Works
Infections, such as UTIs, occur when bacteria use their hook-like arm, known as a fimbraie, to latch onto the urinary tract walls and form a collective known as a biofilm. As this biofilm builds, infections begin to occur.
PaCran® Full Spectrum Cranberry powder inhibits a bacteria's adhesion capability so that biofilm cannot be formed. Because they are unable to bind to cell walls, they are flushed out of the urinary tract.Found in: D-Mannose + Cranberry
Cranberries are a great source of Vitamin C. By adding more Vitamin C we increase the effectiveness of the polyphenols, or antioxidants, in the Cranberries.
What science shows
Bacterial Anti-Adhesion Activity
Cranberries inhibit the adhesion of E. coli to urinary tract cells, preventing biofilm formation and subsequent infection. Evidence from research published in 2011 and 2012 suggests that whole cranberry matrices actually outperform PAC-rich fractions.
Pacran® continues to demonstrate increased activity even after 24 hours, while the PACs cranberry extract’s activity drops off after only 10 hours. These results indicate Pacran®’s superior preventive potential over PAC-rich cranberry extracts.
INCIDENCE OF UTIs at 500mg Dose of PaCran®
At 90 days, there was a 36% reduction of urinary E. coli infection reported in the Pacran® group. These results show that a daily dose of Pacran® reduces urinary E. coli levels when compared to baseline and consequently helps to support a healthy urinary tract.
A 180-day clinical trial was conducted on 176 women prone to UTIs in order to evaluate Pacran®’s ability to reduce recurrent episodes. Results indicated that a daily 500 mg dose of Pacran® reduced UTI recurrences by 58% compared to placebo.
Only clinically proven ingredients
1. A Randomized, Double Blind, Controlled, Dose Dependent Clinical Trial to Evaluate the Efficacy of a Proanthocyanidins Standardized Whole Cranberry (Vaccinium macrocarpon) Powder on Infections of the Urinary Tract
K. Sengupta1, K.V. Alluri1, T. Golakoti1, G.V. Gottumukkala1, J. Raavi1, L. Kotchrlakota1, S.C. Sigalan1, D. Dey2, S. Ghosh2and A. Chatterjee3, *
2. Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection?
Jitka Vostalova,1 Ales Vidlar,2* Vilim Simanek,1 Adela Galandakova,1 Pavel Kosina
3. iii. Assessment of bacterial anti-adhesion activity of PaCran®® in human urine against P-type uropathogenic Escherichia coli. A randomized, placebo-controlled, ex vivo, double-blind, crossover trial.
Amy Howell, Ph.D., Associate Research Scientist, Rutgers University
Check out the 1578 studies
Common Myth Busted:
PACs are gaining attention as being known as an active phytochemical in cranberry for urinary tract health and to fight off Urinary Infection. This began when The French Food Safety Authority published a urinary tract health claim based on 36 mg of North American Cranberry PACs.
The claim came into light in 2004 when the daily dose of 36mg of North American Cranberry (Vaccinium Macrocarpon) as a result of a measurement of total DMAC PACs in a 300ml glass of 27% cranberry juice cocktail.
However, the French food authority rejected the claim on December 17th, 2012 when proof arose of Method, or testing, manipulation, adulteration, new inconclusive evidence published and new negative opinions regarding the AFFSA claim.